CHAMP1- Mice models updates
This is a consolidated view of all mice models about CHAMP1 and their latest updates.
It seems that the most likely scenario is that loss of CHAMP1 protein confers a phenotype in Heterozygous and Homozygous mice that is mouse strain-dependent..
A key takeaway is that homozygosity for loss of function is lethal on both B6J and B6N backgrounds but can be tolerated on a (B6 x BALB/c)F2 mixed genetic background. As humans contain a segregating genetic background the Japanese data may be more translationally relevant.
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