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The CHAMP1 Foundation is an organization created for parents of children with developmental delay, hypotonia, cerebral palsy, autism, and epilepsy among others diagnosed as a result of a change in the CHAMP1 gene.
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CHAMP1 NEWS - October Newsletter 

CHAMP1 CHALLENGE:
FLIP UP FOR A CHAMP1
CHAMP1 Research Foundation is launching today  (1st October) our online fundraising campaign "Flip up for CHAMP1"

Our goal is to raise funds for research and treatments.

What is the challenge and how can you help? 
Create and post a video following the below instructions.

#flipupforCHAMP1

Donate here
NFL SUPERSTAR REUBEN FOSTER IS IN OUR PODCAST THIS MONTH and KICK OFF FLIP UP CHALLENGE
We interview Reuben Foster who is kicking off our CHAMP1 Challenge #flipupforCHAMP1, give a news update & get back to the basics in our new segment CHAMP101.

Thanks for tuning in!
🏈 Reuben met Lily and Ashley during his summer training and is being a great supporter for CHAMP1 Foundation.

You can listen on your phone or computer for free at Spotify, Apple podcastsAmazon music Audible and Podbean.

Listen to the last episode now »
Reuben kick off our challenge! Check on his Instagram @ferrarifoster
Donate here
CHAMP1ON ACHIEVEMENT OF THE MONTH

Lucca has just learned how to swing! 


This achievement is being celebrated by his family as he is showing such a nice control of his strength and balance!
Well done Lucca! 👏🏻👏🏻👏🏻👏🏻👏🏻👏🏻

More about this CHAMP1ON here »

RESEARCH UPDATES AND REPORTS

CHAMP1- Mice models updates


This is a consolidated view of all mice models about CHAMP1 and their latest updates.

It seems that the most likely scenario is that loss of CHAMP1 protein confers a phenotype in Heterozygous and Homozygous mice that is mouse strain-dependent.. 

A key takeaway is that homozygosity for loss of function is lethal on both B6J and B6N backgrounds but can be tolerated on a (B6 x BALB/c)F2 mixed genetic background.  As humans contain a segregating genetic background the Japanese data may be more translationally relevant.

Contact the foundation to know more about it»

Check the table for more details: click to expand



Excited to announce our latest partnership and the future of Gene Therapy for kids affected with CHAMP1

CHAMP1 Foundation is partnering with Columbus Children’s Foundation to gain access to lower-cost manufacturing and CMC expertise to enable the clinical trials of our Gene Therapy Project. 

 

CFC’s mission is to accelerate the most effective gene therapy treatments for children with ultra-rare diseases.

Contact the foundation to know more about it»

CHAMP1 ON THE NEWS

Jeff shared his story and what is going on in research

"A major milestone that we met was being able to advance research in our animal models. There are now several genetic mouse models in the US and a rat model underway in Edinburgh, Uk. One promising model at UC Davis is expressing a phenotype with characteristics similar to our kids. It is still early in preliminary testing but may serve as a good model for translational research."
 
Read the full article here: https://www.rarerevolutionmagazine.com/blog/jeff-dangelo-founder-of-champ-1-research-foundation-tells-his-rare-story

HOW TO SUPPORT?

Fundraise website - CHAMP1 families 

CHAMP1 families are using this platform to fundraise, check now which team you would like to support. 

Donate here

CHAMP1 shop

Check our shop, we have t-shirts and other products to support the Foundation. 

Check our shop >>

If you are a researcher 

Please contact our Foundation and we'll connect you with all research groups involved with CHAMP1 initiatives. 

Contact us >>
 
If you're a CHAMP1's parent

There are loads of ways to support the Foundation and its initiatives, from participating in studies to engaging with fundraising. 

Chat with a CHAMP1 parent >>
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CHAMP1 Research Foundation
Our mission is to improve the lives of those affected by CHAMP1 disorders through clinical research, effective treatments, public awareness, early detection, family support and patient advocacy.

Our mailing address is:
info@champ1foundation.org

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CHAMP1 Research Foundation · 1367 Whitewood Ave · Spring Hill, FL 34609-6165 · USA

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